Because of this high genomic similarity bats have been considered as a natural virus host. Human SARS-CoV-2 express 96.2% genomic similarity to bats’ coronavirus. Origin, transmission, and characteristics of SARS-CoV-2 We presume that even reports based on sparse cohorts could be valuable at this time and may lead to further better disease understanding and treatment. Because of COVID-19 novelty, randomized controlled studies and precise recommendations for COVID-19 management are not available yet. Studies on which this article was prepared were not limited to large cohorts, as a vast majority of reports were based on small cohorts. Therefore, the total number of 50 studies were finally chosen to prepare this manuscript.
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1740 articles were excluded after abstract or full-text analysis because they did not exactly address the topic. The search included articles without language limitations.Ī total of 1790 articles were originally identified using our search criteria. Opinions of medical societies were also included if applicable. Auto alerts in Medline were also considered, and the reference lists of original articles and review articles were searched for further eligible sources.
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Boolean operators (NOT, AND, OR) were also used in succession to narrow and broaden the search. The Medline and Web of Science databases were searched without time limit but focusing on the newest report, using the terms “COVID-19”, “SARS-CoV-2”, “novel coronavirus”, and “coronavirus from Wuhan” in conjunction with “otorhinolaryngological manifestation”, “ENT”, “ear”, “nose”, “throat’’, “oral cavity”, “pharynx”, “larynx”, “hearing”, “vertigo”, “head and neck”, and “olfaction”.